Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D; community with critical information on the tools, technologies, and trends that drive the biotech industry.
Issue link: http://gen.epubxp.com/i/695748
Contents GENengnews.com • Volume 36, Number 13 • July 2016 6 Sticky Ends 8 Industry Watch 11 Products & Services 14 Discovery & Development 21 Genomics & Proteomics 29 Bioprocessing 31 Molecular Diagnostics 32 Clinical Trials 34 New Products 36 Calendar 37 People 38 Best Science Apps News Features Tutorials Drug Discovery Tutorial 16 Engineering the Right Microplate for Tomorrow's Therapeutics Pure polypropylene, says Wheaton, ensures superior performance in microplates that are to be used for protein storage, high-throughput protein discovery, and LC/MS bioanalysis. Assay Tutorial 22 Measuring Proteins on a Massive Scale SomaLogic explains how SOMAmer (Slow Of-rate Modifed Aptamer) reagents bring high afnity and specifcity to proteomic assays and enable high-throughput multiplexing. Bioprocessing Tutorial 28 Scalable Production of Infuenza Virus A single-use, stirred tank bioreactor process from MilliporeSigma allows for scalable, cell-based production of viral vaccines, and avoids the drawbacks of egg-based production. Columns Point of View 8 Driving Down Healthcare Spending Despite ongoing costs related to billing and insurance-related activities in the U.S., savings related to personalized medicine technology will (eventually) reduce healthcare spending. Corporate Profle 10 Getting the Hang of 3D Liver Microtissues InSphero's new microtissue platform incorporates hepatocytes from multiple donors to exemplify genetic diversity and enable more predictive modeling of drug-induced liver injury. Bioprocessing Perspectives 26 JHL Biotech Opens Biosimilars Facility A Taiwan-based biopharma decides it pays to think inside the box—or boxes, provided they are prefab modules from GE Healthcare that quickly ft together to form a biologics plant. 35T H A N N I V E R S A RY F E AT U R E 33 Future Trends in Aging Research Aubrey de Grey, tireless advocate of biomedical gerontology, insists that as translational research exhausts calorie-restriction approaches (ways of limiting damage), it will shift to repair modalities. New Dimensions in 3D Cell Culture Three-dimensional cell culture has two dimensions—the inward, where microtissues nestle, and the outward, where matrices, gels, and microcavities provide support and sustenance. Admittedly, each dimension has its own ins and outs. 1 Homing In on Directed Imaging Platforms Imaging systems are combining specifc labels and sensitive detectors to track MRI, PET, and bioluminescence signals, the better to resolve subcellular details. What's more, these systems are incorporating high-throughput workfows. 30 If "Overall" Underwhelms, Try RNA-Seq A cell population, like a multicultural polity, is more of a mosaic than a melting pot. So, to conduct cellular censuses—in developing tissues, tumors, and microbiomes—sequence deeply and appreciate transcriptomic heterogeneity. 18 Peptide Therapies Are Due for a Gut Check That peptide drugs are on everyone's lips shouldn't be hard to swallow. With better delivery and permeability technologies, peptide drugs are not only diverse and manufacturable, they are also more available via the oral route. 1