Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D; community with critical information on the tools, technologies, and trends that drive the biotech industry.
Issue link: http://gen.epubxp.com/i/716943
38 | SEPTEMBER 1, 2016 | GENengnews.com | Genetic Engineering & Biotechnology News For more information, visit our website (GENengnews.com), click on New Products, and search through our comprehensive new products database. NEW PRODUCTS Development-Scale Freeze/Thaw System The Zeta lab The Zeta lab-scale freeze and thaw system allows re- searchers an searchers and development scientists to study the key factors that factors that influence protein stability: cold denaturation, cryoconcent cryoconcentration, and surface stresses, as well as set the parameters f parameters for successful scale-up. The system features a small work a small working volume of 200 mL with 12 ports for sampling an sampling and 7 temperature sensors for on-line monitor- ing. The syst ing. The system benefits from experience optimizing the freezing pro freezing process in a quality by design approach based on pro based on process modeling and from ye and from years of sup- plying pilot- plying pilot- and production- production-scale freeze and th freeze and thaw systems. Zeta Biopha Zeta Biopharma www.zeta.c www.zeta.com Heating Block for Small Vials The DrySyn Heating Block line enables scientists ock The DrySyn Heating Block line enables scientists line enables scientists to now conduct precisely controlled heated/ ely to now conduct precisely controlled heated/ controlled heated/ stirred experiments in 3 Dram vials, 20 mL Scintil- 3 stirred experiments in 3 Dram vials, 20 mL Scintil- Dram vials, 20 mL Scintil- lation vials and 2 mL HPLC sample vials. The PLC lation vials and 2 mL HPLC sample vials. The sample vials. The new multiposition blocks when combined blocks when combined with a DrySyn base unit allow up to 27 base with a DrySyn base unit allow up to 27 unit allow up to 27 experiments to be performed in paral- o experiments to be performed in paral- be performed in paral- lel. The heating blocks enable clean, g lel. The heating blocks enable clean, blocks enable clean, safe synthesis without the hazards sis safe synthesis without the hazards without the hazards or problems associated with silicon s or problems associated with silicon associated with silicon oil baths or heating mantles. Made heating oil baths or heating mantles. Made mantles. Made of chemically resistant, anodized y of chemically resistant, anodized resistant, anodized aluminum, the DrySyn range of um, aluminum, the DrySyn range of the DrySyn range of heating blocks offer excellent ing heating blocks offer excellent blocks offer excellent heating performance to over ting heating performance to over performance to over 300ºC and can heat a reaction ºC 300ºC and can heat a reaction and can heat a reaction 25% faster than an oil bath. faster than an oil bath. Asynt www.asynt.com ynt.com www.asynt.com ChIP-Seq Spike-In Normalization Strategy ChIP-Seq Spike-in corrects for techni- cal variation that occurs as a result of the multistep ChIP/ChIP-Seq protocols. The addition of two key reagents, Spike-in Chromatin and Spike-in Antibody to standard ChIP reactions provides a means to track sample variation and normalize the data appropriately. The need to nor- malize whole-genome datasets has become evident in the RNA-Seq com- munity, where spike-in is becoming common practice. The new system is easily implemented and universally applicable to any ChIP experimental set-up. The ChIP Spike-in Chromatin and Antibody reagents and protocol are available for purchase together as well as being incorporated into a variety of Active Motif 's end-to-end ChIP-Seq services. Active Motif www.activemotif.com Multicolumn Chromatography Unit for GMP The EcoPrime® Twin LPLC is the first tw The EcoPrime® Twin LPLC is the first twin-column low-pressure chromatography system low-pressure chromatography system at the pilot scale designed for use in GM the pilot scale designed for use in GMP environments. The system can be con environments. The system can be config- ured to allow drug manufacturers to u ured to allow drug manufacturers to use a twin-column unit in multiple modes a twin-column unit in multiple modes: full continuous purification, integrated full continuous purification, integrated (continuous) batch and batch—with b (continuous) batch and batch—with built in capability to operate columns in se in capability to operate columns in series, parallel, or alternating configurations. parallel, or alternating configurations. Future updates will permit two differe Future updates will permit two different chromatography steps (e.g. ProA / IEX chromatography steps (e.g. ProA / IEX) to be accomplished with the same unit. T be accomplished with the same unit. This new system is poised to become a key new system is poised to become a key component for future biologics pro- grams looking to incorporate continu grams looking to incorporate continuous processing. Lewa www.lewapt.com B Cell Killing Assay Kit These new B cell killing assay kits were designed to facilitate characteriza- tion of immunotherapies targeting B cell cancers, based on assays to be conducted on the xCELLigence Real-Time Cell Analyzers. Precoat- ing the electronic microtiter plate with antibodies enables B cells to be selectively immobilized on the plate bottom where they generate a robust impedance signal and proliferate to confluence. Subsequent addition of effector cells results in target B cell death in a dose-dependent manner that is readily quantified. This real-time killing assay is being used for multiple effector cell types (NK, T, CAR-T) and for combination therapies such as CAR-T cells, checkpoint inhibitors, etc. Acea Biosciences www.aceabio.com Modular Bioreactor System The ambr® 250 modular is an innovative benchtop mini bioreactor system for parallel fermen- tation or cell culture. This system combines a single-use bioreactor ves- sel and expandable system design to allow access to advanced benchtop bioreactor technology for process development. The new modular sys- tem consists of a workstation with 2, 4, 6, or 8 single-use bioreactors, with a working volume range of 100 to 250 mL. The system is fully integrated with liquid reservoirs and syringe pumps, allowing rapid experimental set up and turn around. Once installed, the bio- reactor has all the required process services for parameter control, including pH, DO, temperature, or agitation. Additionally, feeds can be delivered from the reagent reser- voirs via the syringe pumps into the bioreactor. One control unit is capable of control- ling up to eight bioreactor stations independently via touch screen user interface. Sartorius Stedim Biotech www.sartorius.com