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Contents GENengnews.com • Volume 36, Number 15 • September 1, 2016 6 Sticky Ends 8 Industry Watch 10 Products & Services 15 Discovery & Development 22 Genomics & Proteomics 26 Bioprocessing 35 Molecular Diagnostics 37 Clinical Trials 38 New Products 40 Calendar 41 People 42 Best Science Apps News Features Tutorials Assay Tutorial 16 Biochemical Assays for Epigenetic Enzymes Active Motif discusses substrate options for epigenetic enzyme activity assays and explains how judicious substate selection can facilitate epigenetic drug discovery. Drug Discovery Tutorial 18 Screening the Membrane Protein To zero in on membrane protein antibody targets, Integral Molecular has developed the Membrane Proteome Array, a high-throughput flow cytometry platform. Bioprocessing Tutorial 28 How to Efficiently Shake Viscous Culture Broths A new geometrically optimized shake flask design, the Thomson Optimum Growth flask, is put through its paces by PreSens, which makes use of its Shake Flask Reader. Bioprocessing Tech Note 30 On-Line OpticaI Cell Biomass Monitoring When bioreactors are small and cell densities are high, liquid cell cultures defy conventional means of online monitoring. BugLab probes, however, are designed to work within crowded confines. Columns Point of View 8 Protect Stem Cell Science from Stem Cell Quackery Desperate for miracle cures and aware of the therapeutic potential of stem cells, the public is vulnerable to opportunists who sell phony versions of regenerative medicine. Corporate Profile 10 An "in Hand" Assay Is at Hand A new bacterial detection system packs the power of a laboratory into a handheld microfluidic device. Its maker, Fluid-Screen, says it gives gold-standard results in 30 minutes. 35T H A N N I V E R S A RY F E AT U R E 36 Gene Therapy 2016: The Pipeline Is Swelling Gene therapies already in preclinical or clinical trials will soon have company. Flowing through the pipeline are therapies that leverage CRISPR/Cas9 and RNAi platforms and new AAVs. Pharmacogenetics Informs Clinical Practice The circle that is personalized medicine consists of more than just doctor, patient, and patient data. Other elements are in the loop, such as EHR systems that incorporate gene-drug information and updated clinical guidelines. 1 See the Bioprocess, Be the Bioprocess In bioprocessing, you can move out of your comfort zone and push the limits of productivity, all while maintaining Zen-like serenity. How? Practice visualization (online sensing) and mind/body alignment (analytics and automation). 24 Awaken Dormant DNA, Epigenetically Epigenetics isn't limited to studying marks on chromatin; it can also put genetics Epigenetics isn't limited to studying marks on chromatin; it can also put isn't limited to studying marks on chromatin; it can also put chromatin on a hair trigger, bringing spring-loaded action to its bead-on- omatin chromatin on a hair trigger, bringing spring-loaded action to its bead-on- on a hair trigger, bringing spring-loaded action to its bead-on- a-string structures, exposing disease processes to transcriptional crossfire. ring a-string structures, exposing disease processes to transcriptional crossfire. structures, exposing disease processes to transcriptional crossfire. 20 Dynamic Shifts in Protein Profiling We're used to tracking economic and political trends, but now audits and polls are getting proteomic, sifting protein populations through finer demographic screens, projecting outcomes for formerly unquanti- fiable biological processes. 1