Genetic Engineering & Biotechnology News

APR15 2017

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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30 | APRIL 15, 2017 | GENengnews.com | Genetic Engineering & Biotechnology News For more information, visit our website (GENengnews.com), click on New Products, and search through our comprehensive new products database. New Products UHPLC System The new Elute series of UHPLC systems provides reproducibility for small molecule LC-MS/MS analysis in food and forensic testing, clinical research, and chemistry. The heart of the Elute series of UHPLC systems are binary linear driven pumps that deliver virtually pulse-free, reproduc- ible flow rates with a unique accuracy that will generate confidence in your results. Built for any routine lab applications the Elute SP offers stan- dard 700 bar performance and the Elute UHPLC delivers high-end, 1300 bar performance for ultrafast LC-MS/MS applications. All Elute systems are designed to minimize gradient delay volume, providing the benefit of short run-to-run times, and saving time in daily routines. Bruker www.bruker.com Protein L Chromatography Resin TOYOPEARL AF-rProtein L-650F, a Protein L resin that exhibits the highest binding capacity for antibody fragments that lack a Fc- portion (e.g., Fab, ScF Dab, etc.). This new resin offers the high binding capacity, but also has the ability to bind to antibody classes that do not have the affinity to Protein A, such as IgM and IgA. The selected recombinant protein L ligand used in the TOYOPEARL AF-rProtein L-650F resin is alkali stable and therefore able to with- stand the high alkaline conditions necessary for clean-in-place (CIP). This resin exhibits stability in various solutions and over a wide pH range, as well as demonstrates excellent pressure-flow rate properties. Tosoh Bioscience www.tosoh.com Managing Impurity Profile Information LUMINATA™ is an informat- ics system that enables organizations to establish effective impurity control strategies. This is accom- plished through the assem- bly of analytical, chemical, and process information—all in a single enterprise informatics environment. Built on a vendor agnostic platform, Luminata offers data standardization and visualization for comprehensive substance impurity characterization, as well as the associated formation and fate of impurities, with chromatographic and spectral data. This new informatics system suits Quality by Design (QbD) approaches in accordance with various industry practices and regulatory requirements. Moreover, Luminata assists pharmaceutical development organizations in their efforts to char- acterize and control materials and substances through their lifecycle. ACD/Labs www.acdlabs.com Bioassay for Improved Quality Control Testing MEGA™ is a new mouse embryo assay that measures gene expression for quality control testing of raw materials used for the manufacture of media for in vitro fertilization (IVF). In studies, MEGA demonstrat- ed increased ability to detect embryotoxic materials that could adversely affect embryo development. The mouse embryo assay (MEA) has been long used as the standard method of testing raw materials and components used in IVF media and assisted repro- ductive technologies (ART). MEGA employs a func- tional molecular biomarker to improve the detection of toxic media or any other environmental stress that may negatively impact early development. The assay measures both the early fluorescence intensity (EFI) and location of fluorescence produced by green fluorescent protein (GFP), which is expressed under the control of the Oct4 promoter. In recent studies, MEGA was able to detect toxicity at considerably lower levels than MEA. Irvine Scientific www.irvinesci.com Single-Use Flowmeters The SumoFlo ® flowme- ters are specifically de- signed to provide single- use flow-measurement solutions for biopharma- ceutical manufacturing applications including: tangential and depth filtration, buffer dilution, cell-culture solutions, chromatography, pure water, or ultrahigh purity chemicals or hygienic fluids with varying den- sity or viscosity. These flowmeters are capable of measuring flow rates from 50 gm/min up to 100 kg/min with an accuracy of ± 1% of reading. Fabricated from PEEK (polyether ether ketone), flowmeters are certified to meet USP Class VI, USP 661, and USP 788. Malema www.malema.com Protein Expression System Vmax™ Express is a fast-growing bacterial strain designed for high-level protein expression. This next- generation protein expression system can replace slow-growing E. coli systems prone to low yields and the genera- tion of insoluble inclu- sion bodies. Vmax cells are derived from Vibrio natriegens, a fast-growing marine bacterium. This gram-negative, nonpatho- genic bacterium doubles twice as fast as E. coli, produces greater amounts of biomass, and generates larger amounts of protein in a shorter time period. Synthetic Genomics www.syntheticgenomics.com

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