Genetic Engineering & Biotechnology News

APR15 2017

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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Target Engagement in Live Cells With the NanoBRET ™ TE Assay you can: • Measure Target Engagement in Live Cells • Directly Measure Compound Residence Time • Use Full-Length Protein • Assay Kinases, BET BRDs and HDACs To learn more visit: promega.com/ResidenceTime ©2017 Promega Corporation. All rights reserved. 37098424 Direct residence time measurement of JQ1 at binding site on NanoLuc ® -BRD4 Fusion Protein. 13725MA 0 20 40 60 80 120 100 Ti me (minutes) Tr acer only 1,000nM JQ1 with w ashout 20,000nM JQ1, no w ashou t BRET Ratio (mBU) 0 10 20 30 40 Compound residence time measurement using NanoLuc ® -BRD4 Luciferase Fusion Protein.

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