Genetic Engineering & Biotechnology News

APR15 2017

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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Page 4 of 37

Predict Drug Toxicity without Guesswork Well begun is half done. This truism surely applies to ADME-Tox testing, which can identify problems early on if the right in vitro, in silico, and animal models are used. Consider organs-on-chips, pathway simulations, and transgenic mice. 8 Contents • Volume 37, Number 8 • April 15, 2017 A Better Environment for Tissue Repair If your body came with a user's manual, you could look up warranty- extending maintenance and repair procedures. These would likely direct your attention to supportive tissues and extra- and intracellular mechanical and chemical factors. 1 Finding Targets in Cancer's Metabolic Quirks Cancer is so energy-hungry that it must use metabolic shortcuts— which means that cancer cells could be starved, and healthy cells spared, if these shortcuts were blocked. To head cancer off at the pass, take directions from pathway analysis. 1 Cell-Line Development Poised for Growth Better culture can enhance the output of protein-expressing cells, but for real gains, try engineering better cell lines. Ensure transgene integrity and localization, epigenetically tweak expression, run selection screens, and track post-translational modifications. 1 8 Corporate Profile 6 Spray-On Stem Cells Can Step Up Healing RenovaCare's autologous skin replacement technology, which gently nebulizes stem cell suspensions, promises to accelerate the healing of burns and wounds. Bioprocessing Perspectives 22 Thermo Fisher Scientific Adopts a Modular Automation Path For enhanced utilization of your bioprocessing equipment and cleanroom space, says Thermo Fisher Scientific, implement scalable control automation systems and software. Drug Discovery Tutorial 12 Integrating Biology and Chemistry for Deeper Understanding Bruker Daltonics describes how matrix-assisted laser desorption/ ionization Fourier transform mass spectrometry (MALDI-FTMS) can characterize drug candidates. Bioprocessing Tutorial 24 Biomass Monitoring in a S. fruticosa Culture The SFR vario instrument from PreSens can monitor plant cell-suspension culture. The device's online measurements of biomass and oxygen reflect metabolic behavior. 4 Sticky Ends 6 Industry Watch 11 Discovery & Development 16 Genomics & Proteomics 22 Bioprocessing 28 Molecular Diagnostics 30 New Products 32 Calendar 33 People 34 Best of the Web 26

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