Genetic Engineering & Biotechnology News

JUL 2017

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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View It Now! On Demand DURATION 60 minutes COST Complimentary Speakers Win More Biologics Development Battles with Early Stability Analysis Biophysical and chemical properties are critical factors that can dictate success or failure in the development of therapeutic antibodies. These attributes and all the functional characteristics of antibodies depend on amino acid sequence, post-translational modifications, and the solution environment. Early quality control and risk assessment of biophysical parameters help prevent failure in later stages of antibody development. An early-stage developability workflow was designed to set stage gate for molecules progressing to late-stage development. Application of the Uncle platform in antibody selection will be presented in this webinar. Stability analysis of engineered antibody variants was evaluated using Intrinsic Fluorescence Conformational Stability (T m ) and Colloidal Stability (T agg ). B 22 /k D parameters for monoclonal antibodies (mAbs) in solution were determined and validated by Small-Angle-X ray-scattering (SAXS). Quantitative correlation between T agg and particle size for mAbs was observed in this study. A live Q&A session will follow the presentations, offering you a chance to pose questions to our expert panelists. Who Should Attend • Researchers developing monoclonal antibodies • Drug discovery scientists • Investigators interested in biologic stability • Biochemists • QC/QA scientists Free Registration! www.GENengnews.com/stability-analysis Webinars You Will Learn • How to use T m and T agg measurements to evaluate the stability of engineered antibodies • How the aggregation propensity parameters B 22 and k D can help further evaluate antibody variants • How the Uncle platform can collect multiple measurements earlier, with less sample Dina Finan, Ph.D. Product Manager Unchained Labs Sam Wu, Ph.D. Principal Scientist Janssen BioTherapeutics Produced with support from

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