Genetic Engineering & Biotechnology News

JUL 2017

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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Genetic Engineering & Biotechnology News | GENengnews.com | JULY 2017 | 39 For more information, visit our website (GENengnews.com), click on New Products, and search through our comprehensive new products database. New Products Bioreactor with Automated Cell-Culture Analyzer The ambr® 15 automated microbioreactor system combined with a Nova Biomedical (Nova) BioProfile ® FLEX2 automated cell culture enables rapid at-line sample collection and analysis of massive quantities of key cell-culture data. The combined system provides a unique tool to simultaneously run, sample, and analyze a massive number of cell-culture conditions during cell-line and media development by design of experiments (DoE). The integrated software enables automated, parallel process- ing of 24 or 48 single-use bioreactors (10 –15 mL working volume). This allows collection of enormous quantities of cell-culture data, including total and viable cell density, viability, cell diameter, pH, PCO 2 , PO 2 , glucose, lactate, glutamine, glutamate, ammonium, Na + , K + , Ca ++ , and osmolality, which can be sampled and measured with a complete cycle time of just 6–7 minutes. Sartorius Stedim Biotech www.sartorius.com Capillary Electrophoresis System For use with oncology research, genome editing, species identification, and human cell-line authentica- tion, among other common applications, the Applied Biosystems™ SeqStudio™ Genetic Analyzer supports the growing need for an affordable and easy-to-use capillary electrophoresis platform. The SeqStudio in- strument utilizes an all-in-one cartridge that combines the capillary array, polymer reservoir, and anode buffer, which vastly simplifies preparation and hands-on pro- cessing time. Other innovative features of the system allow customers to access individualized protocols, an intuitive touchscreen, and connectivity to the Thermo Fisher Cloud for remote set up and monitoring, as well as easy data analysis and collaboration. The SeqStudio instrument has a small footprint, with an onboard computer and integrated touchscreen that makes run setup quick, intuitive, and flexible. The system allows sequencing and fragment analysis runs on the same plate without the need to change any consumables. Thermo Fisher www.thermofisher.com Triple Quadrupole Mass Spectrometer The new Ultivo triple quad is optimized to address the food and environmental routine testing segments employing triple quad LC/MS systems for quantitative analyses. It delivers robust performance, superior uptime, and easy serviceability, in a footprint that is 70% smaller than previous instruments. Ultivo provides reproducible, reliable assays that result in exceptional performance in complex matrices; greater ion transmission ef- ficiency leads to optimized sensitivity; and improved, intelligent diagnostics use intuitive readbacks that can quickly identify issues, ensuring optimum uptime. Furthermore, Ultivo's new VacShield vacuum provides ventless ion-injector exchange capabilities that reduce wear and tear and facilitate rapid frontend maintenance. Agilent www.agilent.com Trastuzumab-Binding Protein for ADC Monitoring Orla presents ORLA254, a new trastuzumab-binding protein for simplified assay of trastuzumab binding to its antigen during development and manufacture of antibody-drug conjugates (ADCs). This protein incorporates the Her2 antigen into Orla's proprietary surface binding unit (SBU). The trastuzumab-binding protein has been specially designed to meet this re- quirement and incorporates easy immobilization and application across multiple platforms, such as ELISA, and bioanalytical instruments, such as Biacore and Octet. The product is available as a solution or as pre- coated ELISA plates. Either format enables scientists to quickly and easily test the effect of reaction conditions on the ability of processed trastuzumab to bind its target antigen. Orla Protein Technologies www.orlaproteins.com High-Content Analysis Platform GE Healthcare Life Sciences has released the IN Cell Analyzer 6500HS, a laser-based confocal imaging system, and the IN Cell Analyzer 2500HS, a wide-field high-content imaging system. In conjunction with the IN Carta software, these next-generation systems combine powerful ana- lytics with an intuitive user inter- face to provide fast, quantitative results. The IN Cell Analyzer 6500HS enables a wide range of high-content assays from basic multicolor fixed-cell assays to the most complex live-cell and 3D assays. The system delivers increased throughput and enables the acquisition and analysis of images with exceptional quality and depth for even the most demanding 3D samples, such as spheroids and organ- oids. The IN Cell Analyzer 2500HS, with its ultra-fast scan times and high camera frame rates, is a sensitive, high-throughput system for researchers interested in performing a wide range of functions, from large-scale screens to the study of rapid kinetic events. Equipped with deconvolution, the system is optimized to produce quantifiable data from long-term live-cell imaging experiments and dim samples. GE Healthcare www.gelifesciences.com Live-Cell Imaging Solution The DMi8 S imaging solution from Leica provides 5x more speed, and an increased viewing area up to 10,000x. This can be combined with the new photomanipulation scanner to activate, ablate, and bleach within one experiment. For super resolution and nanoscopy, the Infinity TIRF has been added, allowing simultaneous multicolor imaging with single molecule resolution. The DMi8 modular research microscope is the heart of the DMi8 S system. Every DMi8 microscope can be equipped with up to two Infinity Ports, allowing direct access into the fluorescent light path for addition of the latest in fluorescence technology, such as the Infinity Scanner or Infinity TIRF. Leica Microsystems www.leica-microsystems.com

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