Genetic Engineering & Biotechnology News

JUL 2017

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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4 | JULY 2017 | GENengnews.com | Genetic Engineering & Biotechnology News 140 Huguenot Street, New Rochelle, NY 10801- 5215 914 740 -2100 • GENengnews.com PUBLISHER & CEO Mary Ann Liebert PRESIDENT, GEN Publishing Marianne Russell GEN GROUP PUBLISHER Sande Giaccone EVP, STRATEGIC DEVELOPMENT Kevin Davies, Ph.D. EDITOR IN CHIEF John Sterling editor@GENengnews.com M A N AG I N G E D I TO R Randi Hernandez P R O D U C T I O N E D I TO R Robert M. Reis S E N I O R E D I TO R Kevin Mayer T E C H N I C A L E D I TO R Patricia F. Dimond, Ph.D. T E C H N I C A L E D I TO R Jeffrey S. Buguliskis, Ph.D. S E N I O R N E W S E D I TO R Alex Philippidis C H I E F CO PY E D I TO R Steven Hernacki A R T D I R E C TO R James Lambo COMMERCIAL DIREC TOR Bill Levine ONLINE COORDINATOR Katherine Vuksanaj O N L I N E P R O D U C T M A N AG E R Thomas Mathew W E B P R O D U C E R Melinda Kucsera S A L E S A D M I N I S T R ATO R Fallon Murphy GEN Editorial & Scientific Advisory Board Peter Banks, Ph.D., Scientific Director, BioTek Instruments; Roslyn Brandon, D.V.M., Ph.D., President and CEO, Immunexpress; Robert Clarke, Ph.D., President & CEO, Pulmatrix; Pete Gagnon, Project Director, Downstream Processing, Bioprocessing Technology Institute (Singapore); Uwe Gottschalk, Ph.D., CTO, Lonza Pharma & Biotech; Harry E. Gruber, M.D., CEO, Tocagen; Jin Seok Hur, Ph.D., Technology Director, Novasep; James Inglese, Ph.D., Principal Investigator, Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences NIH; Guenter Jagschies, Senior Director, GE Healthcare Life Sciences; Peter Johnson, M.D., Principal, MedSurgPI; Anis H. Khimani, Ph.D., Head of Strategy & Marketing, Research Reagent Solutions, PerkinElmer; Mikael Kubista, Ph.D., Biotechnology Institute, Academy of Sciences, Czech Republic; Peter Levison, Senior Marketing Director, Downstream Processing, Pall Life Sciences; Jan Lichtenberg, Ph.D., CEO and Co-Founder, InSphero; Miodrag Micic, Sc.D., Ph.D., Professor and Department Chairman, Cerritos College; Eric Schadt, Ph.D., Director, Icahn Institute for Genomics and Multiscale Biology; Zhiwei Song, Ph.D., Scientist, National University of Singapore; Sumio Sugano, M.D., Ph.D., Professor, Medical Genomics, University of Tokyo; John Talley, Ph.D., CSO, SARmont; Bin Wang, Ph.D., Professor, Principal Investigator, Fudan University Shanghai Medical College; Daniel I. C. Wang, Ph.D., Institute Professor of Chemical Engineering, MIT Advertising United States and North America EAST COAST Monica Lieberman 914 740 2173 mlieberman@GENengnews.com SF BAY AREA Sharon Spitz 314 795 4151 sspitz@GENengnews.com MIDWEST/S.EAST Rick Bongiovanni 330 998 9800 rbongiovanni@GENengnews.com WEST COAST Catherine McConville 415 416 8970 cmcconville@GENengnews.com U.K. and Europe Ian Slade +44 7768 397068 islade@GENengnews.com GEN Classified, Asia and Australia Display Victoria Palusevic 914 740 2167 vpalusevic@GENengnews.com All Other Countries advertising@GENengnews.com 914 740 2200 Insertions and Advertising Material Wanda Sanchez wsanchez@GENengnews.com Customer Service & Subscriptions www.GENengnews.com/subscription-center 888 211 4235 847 559 7587 Reprints Karen Ballen reprints@GENengnews.com 914 740 2100 The views, opinions, findings, conclusions, and recommendations set forth in any article in Genetic Engineering & Biotechnology News (GEN) are solely those of the authors of those articles and do not necessarily reflect the views, policy, or position of GEN, its Publisher, or its editorial staff and should not be attributed to any of them. All advertisements are subject to review by the Publisher. The acceptance of advertisements does not constitute an endorsement of the product or service advertised. Genetic Engineering & Biotechnology News (ISSN-1935-472X) is published semimonthly except July, August, and December (twenty-one issues a year) by GEN Publishing, 140 Huguenot Street, 3rd Floor, New Rochelle, NY 10801-5215. Periodicals postage paid at New Rochelle, NY and at additional mailing offices. Postmaster: Send address changes to Genetic Engineering & Biotechnology News, c/o Subscription Department, Mary Ann Liebert, Inc., 140 Huguenot Street, 3rd Floor, New Rochelle, New York 10801-5215. Fax: 914 740-2201. Mailed in Canada under CPC CPM #40026674. Printed in the U.S.A. For subscription information go to: www.GENengnews.com/subscription-center Copyright © 2017 by GEN Publishing, New Rochelle, NY. Mary Ann Liebert, Inc. is recognized as a Certified Woman-Owned Business by the Women's Business Enterprise National Council (WBENC). GENengnews.com Scientists from the University of Illinois report that a species of giant elephant that lived 1.5 million to 100,000 years ago, ranging across Eurasia before it went extinct, is more closely re- lated to today's African forest elephant than the forest elephant is to its nearest living relative, the African savanna elephant.The study challenges a long-held assumption among paleontologists that the extinct giant, Palaeoloxodon antiquus, was most closely related to the Asian elephant. The findings, reported in the journal eLife, also add to the evidence that today's African elephants belong to two distinct species, not one, as was once assumed. Genetics Clarifies the Elephant Family Tree Some people are good at interpreting what you're thinking or feeling, just from looking at your eyes—and some people aren't. If you wanted to identify the people who can "see" your state of mind, you could administer the "Reading the Mind in the Eyes' Test," which measures cog- nitive empathy. Alternatively, you could look at genomic data. Cognitive empathy and genetics were linked in a recent genome-wide meta-anal- ysis that looked at 89,000 people, most of whom were customers of 23andMe. The analysis, led by researchers at the University of Cambridge and the Institut Pasteur, confirmed an earlier finding: Women generally perform better on the Eyes Test. New findings, in Molecular Psychiatry, associate women's scores with variants on chromosome 3. Johns Hopkins researchers report in ACS Nano that they have developed a nanoparticle or "immunoswitch" capable of dramatically slowing the growth of mouse melanoma and colon cancer, even eradicating tumors in test animals. Investigators coated paramagnetic iron particles about 100 nm in diameter with two antibodies, a programmed death ligand 1 (PD-L1) inhibitor, and a stimulator of T cells via the 4-1BB pathway. The goal was to effectively switch off a tumor's immune-inhibiting ability while simultaneously switching on the immune system's capacity to attack, Jonathan P. Schneck, M.D., Ph.D., of Johns Hopkins said. Immunoswitch-treated mice had tumors nearly 75% smaller than untreated animals, while soluble antibody only reduced tumor growth by approximately 25%. Half of immunoswitch-treated mice were still alive after 30 days; all untreated mice died by day 22. Australian researchers are developing a gene-therapy cure for severe allergies. The team recently published their technique in JCI Insight. The challenge in treating allergic reactions is that T cells develop an "immune memory" and become resistant to treatment. But the team's gene-therapy technique can wipe the memory of those T cells, thus desensitizing the immune system to allergen proteins. The method involves inserting an engineered version of the allergen protein-regulating gene into blood stem cells, and then treating the patient with those cells. Focusing first on allergic asthma, the research has ap- plications in many severe allergies including peanuts, bee venom, and shellfish. Sticky Ends ... Genomics Backs Up Ability to Read Minds by Looking into Eyes " Immunoswitch" Means Double Trouble for Cancer Wavebreakmedia / Getty Images Eraxion / Getty Images Asier Larramendi Eskorza and Julie McMahon Gene Therapy Urges T Cells to Forget Asthma

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