Genetic Engineering & Biotechnology News

FEB15 2015

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D; community with critical information on the tools, technologies, and trends that drive the biotech industry.

Issue link: http://gen.epubxp.com/i/457501

Contents of this Issue

Navigation

Page 2 of 41

Growing Pains of Single-Use Systems Speeding Up the Protein Assembly Line This projection comes from a report produced by MarketsandMarkets, which divides the protein engineering market into three applica- tion areas: biotherapeutics, diagnostics, and re- search. Relevant technologies cited in the report include sequence modifcation/glycosylation, pegylation, display technologies, humaniza- tion technologies, hybrid technologies, and transgenic mice. Similar issues were discussed at two recent conferences, CHI's PepTalk (held in San Di- ego) and GTCbio's Protein Discovery Summit (held in Boston). These events featured cutting- edge research and highlighted current challenges and evolving solutions in the feld. Presentations included novel ways of utilizing mass spectrom- etry, new strategies to engineer and express pro- teins in yeast and baculovirus systems, how to better validate biosimilar drugs, and improved instrumentation to assess protein aggregation. The ability to characterize proteins from i nitial sequence to fnal conformation is criti- cally important for delineating the safety and effcacy of protein drugs. "Biological mass spectrometry (MS) provides a variety of see page 10 GE Healthcare Life Sciences' ReadyToProcess single-use platform for biomanufacturing Mass spectroscopy plays a critical role in characterizing the higher order structure of proteins. angelblue1 / iStock "There are still limitations with single-use technolo- gies," remarks Berthold Boedeker, Ph.D., chief sci- entist, global biologics development, Bayer Pharma, "particularly in the areas of pretesting and the quality of disposables, standardization and qualifcation of bags and connections, and validation of leachables and extractables, as well as dependency on individual solutions from different vendors." To be fair, these limitations have not prevented single-use processing from achieving success after success. The successes, rather, are what make the limi- tations stand out. Dr. Boedeker attributes the growing popularity of single-use bioprocessing to rising protein titers, particularly for monoclonal anti- bodies, which have led to smaller Angelo DePalma, Ph.D. Despite its growing popularity, single-use bioprocessing is not an unadulterated joy. It is spotted with process quality concerns. Kathy Liszewski The feld of protein engineering is booming. It represents a market that is projected to reach $168 billion by 2017. see page 22 TO O L S T E C H N O LO G I E S T E C H N I Q U E S February 15, 2015 www.GENengnews.com Sticky Ends... Tattoo Measures Glucose Levels 4 6 microRNA Gems, Transcriptional Settings Court's "Hard" Stance Will Hinder Innovators 16 GEN Roundup: Researchers Catch the Exosome Express 30 Optimizing Stem Cell Culture 26

Articles in this issue

Links on this page

Archives of this issue

view archives of Genetic Engineering & Biotechnology News - FEB15 2015