Genetic Engineering & Biotechnology News

AUG 2018

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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4 | AUGUST 2018 | Genetic Engineering & Biotechnology News | 140 Huguenot Street, New Rochelle, NY 10801- 5215 914 740 -2100 • PUBLISHER & CEO Mary Ann Liebert PRESIDENT, GEN Publishing Marianne Russell GEN GROUP PUBLISHER Sande Giaccone EVP, STRATEGIC DEVELOPMENT Kevin Davies, Ph.D. EDITOR IN CHIEF John Sterling S E N I O R E D I TO R Kevin Mayer T E C H N I C A L E D I TO R Jeffrey S. Buguliskis, Ph.D. S E N I O R N E W S E D I TO R Alex Philippidis S E N I O R S C I E N C E W R I T E R Julianna LeMieux, Ph.D. C H I E F CO PY E D I TO R Steven Hernacki A R T D I R E C TO R James Lambo P R O D U C T I O N E D I TO R Robert M. Reis ONLINE PRODUC TION MANAGER Katherine Vuksanaj C H I E F I N F O R M AT I O N O F F I C E R, V P Joe Cruz COMMERCIAL DIREC TOR Bill Levine D I G I TA L P R O D U C T M A N AG E R Sean Helmes D I G I TA L T R A F F I C M A N AG E R Michelle Stolowicki A S S O C. D I R E C TO R O F M A R K E T I N G Jennifer Gatti S A L E S A D M I N I S T R ATO R Fallon Murphy GEN Editorial & Scientific Advisory Board Peter Banks, Ph.D., Scientific Director, BiotTek Instruments; Roslyn (Brandon) Hendriks, D.V.M., Managing Partner at C-Suite Corporate, The University of Queensland; Robert Clarke, Ph.D., President & CEO, Pulmatrix; Pete Gagnon, Chief Scientific Officer, BIA Separations; Uwe Gottschalk, Ph.D., Chief Scientific Officer, Lonza; Harry E. Gruber, M.D., CEO, Tocagen; Jin Seok Hur, Ph.D., Technology Director, Novasep; James Inglese, Ph.D., Investigator at National Center for Advancing Translational Sciences; Guenter Jagschies, Senior Director, GE Healthcare Life Sciences; Peter Johnson, M.D., Principal, MedisurgePI; Anis H. Khimani, Ph.D., Head of Strategy and Marketing, Research Reagent Solutions, PerkinElmer; Mikael Kubista, Ph.D., CEO and Founder, TATAA Biocenter; Peter Levison, Senior Marketing Director, Downstream Processing, Pall Life Sciences; Jan Lichtenberg, Ph.D., CEO and Co-Founder, InSphero; Miodrag MIcic, Sc.D., Ph.D., Professor and Department Chairman, Cerritos College; Eric Schadt, Ph.D., Founder and CEO, Sema4; Zhiwei Song, Ph.D., Scientist, National University of Singapore; Sumio Sugano, M.D., Ph.D., Professor, Medical Genomics, University of Tokyo; John Talley, Ph.D., Medicinal Chemist, Euclises Pharmaceuticals; Bin Wang, PhD., Professor, Principal Investigator, Fudan University Medical College; Daniel Wang, PhD., Institute Professor of Chemical Engineering, MIT Advertising United States and North America EAST COAST Monica Lieberman 914 740 2173 MIDWEST/S.EAST Rick Bongiovanni 330 998 9800 WEST COAST Catherine McConville 415 416 8970 U.K. and Europe Ian Slade +44 7768 397068 GEN Classified, Asia and Australia Display Victoria Palusevic 914 740 2167 All Other Countries 914 740 2200 List Sales: Scott Perillo 914 740-2178 Insertions and Advertising Material Wanda Sanchez Customer Service & Subscriptions 888 211 4235 847 559 7587 Reprints Karen Ballen 914 740 2100 The views, opinions, findings, conclusions, and recommendations set forth in any article in Genetic Engineering & Biotechnology News (GEN) are solely those of the authors of those articles and do not necessarily reflect the views, policy, or position of GEN, its Publisher, or its editorial staff and should not be attributed to any of them. All advertisements are subject to review by the Publisher. The acceptance of advertisements does not constitute an endorsement of the product or service advertised. Genetic Engineering & Biotechnology News (ISSN-1935-472X) is published semimonthly except July, August, and December (twenty-one issues a year) by GEN Publishing, 140 Huguenot Street, 3rd Floor, New Rochelle, NY 10801-5215. Periodicals postage paid at New Rochelle, NY and at additional mailing offices. Postmaster: Send address changes to Genetic Engineering & Biotechnology News, c/o Subscription Department, Mary Ann Liebert, Inc., 140 Huguenot Street, 3rd Floor, New Rochelle, New York 10801-5215. Fax: 914 740-2201. Mailed in Canada under CPC CPM #40026674. Printed in the U.S.A. For subscription information go to: Copyright © 2018 by GEN Publishing, New Rochelle, NY. Mary Ann Liebert, Inc. is recognized as a Certified Woman-Owned Business by the Women's Business Enterprise National Council (WBENC). Hoxton Tom M erton / Getty Images Center For American Archeology European colonists arriving in the Americas not only displaced indigenous people, they also eliminated native Ameri- can dogs. Yet a sort of relative of these dogs survives—the canine transmissible venereal tumor, a contagious cancer clone derived from a dog that lived up to 8,000 years ago. An international research team has published a study in Science showing that native or "pre-contact" American dogs possessed genetic signatures unlike dogs anywhere else in the world. Researchers sequenced 71 mitochondrial and 7 nuclear genomes from ancient North American and Siberian dogs from timeframes spanning 9,000 years. The investigators found that native dogs arrived alongside people over 10,000 years ago and dispersed throughout North and South America. They rapidly disappeared following the arrival of Europeans, leaving little to no trace in modern American dogs. "People in Europe and the Americas were genetically distinct, and so were their dogs," said Greger Larson, Ph.D., director of the Palaeogenomics & Bio-Archaeology Research Network (Palaeo-BARN) at Oxford and senior author of the study. The phrase "polygenic score" may seem inspired by eugenics. Such a score is a distillation of genetic and lifestyle data, and it tries to repre- sent individual prospects for life outcomes. Most polygenic scores have been used to predict disease risk. But a new polygenic score has been used to predict upward mobility. According to a PNAS study, it predict- ed social mobility in more than 20,000 individuals in the U.S., the U.K., and New Zealand. "Education-linked genetics could encode characteris- tics that help people get ahead in life," said the authors of the paper, an international team of scientists led by researchers at Duke University. While some would say that these "genetic" outcomes could simply reflect "social history"—with well-off families staying well-off and sharing genetic (as well as material) legacies—this study accounts for legacy-pooling genetics by looking for upward mobility in individuals, according to the investigators. The researchers concluded that higher polygenic scoring individuals, while tending to originate from more socioeconomically privileged upbringings, had greater upward mobility even when compared with parents and siblings. The study also concluded that the mother's polygenic score was more of a determining factor than the father's in a progeny's upward mobility. The Genetics of Success Living at higher latitudes, where sunlight is relatively weak, could result in a higher preva- lence of obsessive compulsive disorder (OCD), according to a new study published in the Journal of Obsessive-Compulsive and Related Disorders by researchers at Binghamton University, SUNY. "The results of this project are exciting because they provide additional evidence for a new way of thinking about OCD," said Meredith Coles, Ph.D., professor of psychology at Binghamton University. "Specifically, they show that living in areas with more sunlight is related to lower rates of OCD." Individuals with OCD commonly report not being able to fall asleep until later than desired. Often, they will then sleep in very late in order to compensate for that lost sleep, thus adopting a delayed sleep-wake pattern that may have adverse effects on symptoms. "This delayed sleep-wake pattern may reduce exposure to morning light, thereby potentially contributing to a misalignment between our internal biology and the external light-dark cycle," noted Dr. Coles. "People who live in areas with less sunlight may have fewer opportunities to synchronize their circadian clock, leading to increased OCD symptoms." This misalignment is more prevalent at higher latitudes—areas where there is reduced exposure to sunlight—which places people living in these locations at an increased risk for the development and worsening of OCD symptoms. Living in Areas with Less Sun May Boost Your OCD Risk Ancient Dogs Left Behind Genomic Pawprints Sticky Ends...

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