Genetic Engineering & Biotechnology News

NOV1 2018

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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GENengnews.com | Genetic Engineering & Biotechnology News | NOVEMBER 1, 2018 | 31 For more information, visit GENengnews.com New Products IVF Plasticware Irvine Scientific recently acquired U.S. distribution rights to Corn- ing's Falcon ® IVF dishes and plate line. The Falcon IVF line features a range of specialty culture dishes and plates, designed for the sophisticated needs of the IVF market. All Falcon IVF plasticware is manufactured from crystalline polystyrene, which is tested for USP Class VI cytotoxicity and is ideal for applications like oocyte preparation, as well as fertilization, culture, and transfer. The line meets applicable U.S. FDA regulatory compliance, quality assur- ance, and 510 (K) requirements. Irvine Scientific www.irvinesci.com Film-Deposition Monitoring The SpectraLock Optical Monitoring System provides in situ monitoring and deposition rate control to produce single- and multi- layered thin films with exacting accu- racy, time after time, without iteration or error. It is an innovative optical monitoring system with exceptional precision and unmatched thin-film reproduction capabilities. The advanced system produces optical coatings to the pre- cise specifications of the original optical design because of its index dispersion enhanced optical monitoring (IDEM) features. Using SpectraLock, a single test run can confirm that the coating matches its design, instead of the traditional method of performing multiple test runs until a coating iteration comes close to matching the design. Eddy www.eddyco.com Fluorescent Labels A range of five new Alexa Fluor ® labels for Lightning- Link ® antibody labeling kits is now available. The addi- tion offers customers increased choice and flexibility for common fluorescence detection–based applications. The use of secondary antibodies within fluorescent imaging applications is commonly associated with issues such as high-background fluorescence and non-specific binding. The combination of Alexa Fluor labels with Lightning-Link technology overcomes these problems, by enabling easy, direct conjugation of the label to primary antibodies in less than 20 minutes. The Lightning-Link protocol is free of separation steps, saving researchers time and precious materials. Expedeon www.expedeon.com Recombinant mAbs A range of recombinant monoclonal antibodies (mAbs) anti-ranibizumab that are highly specific for the mAb drug ranibizumab (Lucentis) or the complex of ranibizumab with its target, vascular endothelial growth factor A (VEGF-A). Ranibizumab is used for the treatment of wet age- related macular degen- eration (AMD), a common form of age-related vision loss, and for macular edema and diabetic retinopathy. The anti-ranibizumab antibodies are inhibitory, non-inhibito- ry, and drug-target complex-specific antibodies and designed for use in pharmacokinetic (PK) and immunogenicity assays for ranibizumab and biosimilars. These anti-idiotypic antibodies are generated using Human Combinatorial Antibody Library (HuCAL ® ) and CysDisplay ® , a pro- prietary method of phage display with guided selection methods to obtain highly targeted reagents. The recombinant production method also ensures a consistent and secure supply. Bio-Rad Laboratories www.bio-rad.com Benchtop Spectrophotometer The IRSpirit Fourier Transform Infrared (FTIR) spectrophotometer provides scientists with superior expandability and space efficiency in their labs. Its small-space design allows access from two sides, and its sample compart- ment is the widest of any other com- pact FTIR spectrometer. In addition to its size, the sample compartment has been designed for maximum flexibil- ity. It accommodates existing accessories such as ATR and diffuse reflectance, as well as transmission accessories such as a KBr pellet holder and demountable cells. The IRSpirit includes a sealed interferometer that protects the beam splitter from both air and moisture. It also houses electrical humidity and paper-based indicators, which work in tandem with LabSolutions IR software, to help users easily monitor the status of IRSpirit in high-humidity environments. Shimadzu Scientific Instruments www.ssi.shimadzu.com Impurity Analysis Kit The Gyrolab ® CHO-HCP E3G kit is designed for impurity analysis in the CMC (chemistry manu- facturing and controls) bioprocess workflow of biotherapeutics. The kit, developed as part of a licensing and supply agreement with Cygnus Technologies, quantifies residual host cell proteins (HCP) from CHO cells used in bioprocessing, one of the critical analyti- cal steps in ensuring the safety of thera- peutics. The new kits have a broad dynamic range and show low intra- and inter-assay variation, increasing productivity in host cell protein analysis in bioprocess development. The new Gyrolab CHO-HCP E3G kit provides consistent and sensitive assay performance without the need for extensive assay development. Gyrolab technology includes optimized, ready-to-use kits, which simplify assay workflows and shorten run times. Some users have reported a 40% reduction in project times versus alternative technologies. Gyros Protein Technologies www.gyrosproteintechnologies.com

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