Genetic Engineering & Biotechnology News

NOV1 2018

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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Contents • Volume 38, Number 19 • November 1, 2018 What's Trending Online G E N N E W S H I G H L I G H T S Immunotherapy Pioneers Take 2018 Nobel Prize G E N N E W S H I G H L I G H T S Marijuana Use Could Be Worse for Cognitive Development in Ado- lescents Than Alcohol G E N N E W S H I G H L I G H T S Nobel in Chemistry Awarded for Directed Evolution of Enzymes and Antibodies I N S I G H T & I N T E L L I G E N C E The Award of "Scientific Heroines" Honors Dr. Jennifer Doudna Pixabay KatarzynaBialasiewicz/Getty Images Karla Shepard Rubinger Johan Jarnestad/The Royal Swedish Academy of Sciences Biomanufacturers Take the Heat off Their Cell Lines Simple or complex, biopharma production always comes down to the tiny processing facilities we call cells. If you characterize cell lines well, you can bank on them. In fact, you'll have to—cryogenically speaking. 16 Do CRISPR Risks Outweigh Rewards? Would that CRISPR risks were limited to off-target effects or the realization of dystopian visions. Alas, the risks also include licensing disputes, which could cool innovation as much as the absence of useful research tools. 29 Precision Biomarkers and Medicines Go Global For developers of predictive biomarkers and companion diagnostics, globalization refers to the forging of intellectual supply chains. These chains can link diverse and far-flung platforms, partners, and commercial activities. 1 The Scoop 6 Top 10 U.S. Biopharma Clusters Biopharma resources—educational, scientific, and financial—are becoming increasingly concentrated in fewer places. If "biopharma rich" regions keep getting richer, will the "biopharma poor" ever catch up? 4 Sticky Ends 30 New Products 32 Calendar 33 People 34 Best Science Apps Unravelling the Secrets inside Single Cells Single-cell analysis is not so preoccupied with transcriptomes that it misses heterogeneity at the proteomic and metabolomic levels. It is also noticing how subcellular localization can vary among seemingly similar cells. 1 Bioprocessing Tutorial 22 Improving Cell Culture Outcomes through Stabilized bFGF Basic fibroblast growth factor (bFGF) isn't so basic, given its sensitivity to heat. But a stable recombinant bFGF, from Thermo Fisher, can simplify cell culture workflows and improve 2D and 3D culture results. On Your Radar 8 Microfluidic Dragnet Catches Most-Wanted Antibodies The long arm of GigaGen is reaching out for antibodies of interest. Combining microfluidics, genomics, and protein library engineering, the company is looking to do more than round up the usual suspects. Flow Cytometry Breaks with Tradition As always, flow cytometry is forcing cells to pass detectors in single file. But it is also looking into cells more deeply than ever, allowing single-cell analysis to fan out and explore many paths to new applications. 14 R O U N D U P

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