Tools | Technologies | Trends
VOLUME 33, NUMBER 14
Biobusiness
AUGUST 2013
Day 5 blastocyst. The holding
pipette and the injection pipette are
shown. After aspiration, the fluid
is stored in an Eppendorf tube and
immediately analyzed. Blastocoele
fluid content seems to be useful for
pre-implantation genetic diagnosis
and to detect viability of the embryo
without removing embryonic cells.
Big Need
in IBD:
Drugs to Slow
Progression
Cervesi Hospital Cattolica
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Drug Discovery
Hematologic
Diagnostics
Go with the
Flow
16
OMICS
RT-PCR:
Ready for
Prime Time?
24
Diving Deep with Array CGH
Richard A. Stein, M.D., Ph.D.
While single-nucleotide polymorphisms were an initial focus, the subsequent discovery of
copy-number variation unveiled a new dimension of genomic diversity, and made apparent
the need to develop more refned technologies to capture chromosomal rearrangements.
Comparative genomic hybridization (CGH) provided the opportunity to detect chromosomal imbalances in a high-throughput manner, at the genome-wide scale, and with higher resolution than with previously available methods, such as G-banding and fuorescence
in situ hybridization. At the same time, the wealth of CGH data generated gave rise to several challenges.
"Identifying the genomic changes that are signifcant is a challenging aspect of CGH array data
see page
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Bioprocessing
Novel CHO
Suspension
Cell
Cultivation
32
Still a Place for Steel and Glass
A major driver
for bioreactor
R&D; comes from
the renewable
Translational
Medicine
energy sector.
Here, an Infors
Molecular
Imaging
Driving
Development
34
scientist performs an SSF
(simultaneous
saccharification
and fermentation)
where cellulose is
transformed into
bioethanol.
GE Healthcare
Life Sciences
Angelo DePalma, Ph.D.
The diverse bioreactor market, consisting of
glass, stainless steel, and plastic, has been heating up as the center of gravity for industrial and
pharmaceutical biotechnology disperses away
from Europe and the U.S. to Asia, South America, and the Pacifc Rim.
"New markets are emerging especially in biofuels and second- and
third-generation bioprocesses," says Eric Abellan, product manager for
bioreactors at Infors. Interest in application-specifc bioreactors and incubation shakers for photosynthesis and simultaneous scarifcation and
fermentation is increasing, as well.
see page
Bioreactors have always been specifed on the
Ingredients for success: ImageQuant LAS 500
Let your imagination run wild, not your Western Blotting data.
imagination at work
www.gelifesciences.com/researchsolutions/wb
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