Genetic Engineering & Biotechnology News

JUL 2017

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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38 | JULY 2017 | | Genetic Engineering & Biotechnology News For more information, visit our website (, click on New Products, and search through our comprehensive new products database. New Products PCR Purification Kit Empirical Bioscience's new PCR Purification Kit streamlines the DNA purification process and delivers high-yield recovery. Designed with efficiency in mind, the kit arrives with the essential components including, binding buffer, activation buffer, elution buffer, washing buffer, spin columns, and collection tubes. It allows for efficient DNA purification, providing maximum recovery of linear or circular DNA ranging in size from 100 bp to 10 kb while simultaneously removing primer-dimers, prim- ers, nucleotides, proteins, salt, loading dyes, and other impurities. Based on silica-membrane technology, the extraction kits allow for the binding of DNA in high-salt and elution in a low-salt buffer, and is designed to work with DNA amounts of up to 20 µg, so no organic extractions or additional precipitations are necessary. This helps to guarantee high and stable recovery rates. Empirical Bioscience Two-Lens Crystallization Plate The Swissci UVXPO 2 Lens Crystallization Plate is made from a new polymer mixture that means crystals can be viewed in UV, polar, and visible light. The dual-cham- bered plate has typi- cal reservoir volumes are 50–100 μL and 50 nl–5 μL drop size. The 192 optical wells allow easy crystal viewing and retrieval. Raised wide wells make the crystal mounting especially easy, and wide partition walls between the wells give plenty of area for good sealing with tape. Swissci RNA Library Prep Kits The strand-specific NEBNext Ultra II Directional RNA Library Prep Kit and the nondirectional NEBNext Ultra II RNA Library Prep Kit are both designed for Illumina next-generation sequencing (NGS) systems. The kits are compatible with poly(A) mRNA isolation and ribosomal RNA (rRNA) depletion, and libraries can be con- structed from a substantially broader input range (5 ng to 1 µg of total RNA) at high yields. Library complexity and transcript coverage are excellent, even at low-input amounts and when researchers are working with low-quality samples, such as formalin-fixed, paraffin-embedded (FFPE) RNA. NEB's protocols for constructing RNA libraries with Ultra II, including rRNA depletion or poly(A) mRNA enrichment, require less than 30 minutes hands-on time and can be finished in about 6 hours. New England Biolabs Synthetic Human Fab Fragment Library This fully synthetic antibody library, built using the COLIBRA™ DNA library synthesis method, takes advantage of the most up-to-date understanding of the human antibody repertoire. Combining massive sequence diversity and dispersity with high functional- ity and developability, it offers the most efficient route to therapeutic antibody lead identification. This library is offered in the industry standard phagemid display format to allow for immediate integration into existing workflows. Isogenica's fully synthetic human Fab antibody fragment library takes advantage of data derived from the mass sequenc- ing of natural repertoires and the structural resolution of antibody-antigen interactions. These data resources allow Isogenica's designers to accommodate the local structural environment within vari- able domains when designing fragment libraries. This maximizes active functional diversity and minimizes post-translational liabilities. Isogenica Bioprocess Control Station The BioFlo 120® is the latest bench-scale fermentor/ bioreactor system for research and development. This flexible instrument is capable of microbial fermentation as well as mammalian cell culture applications with a single platform. It features an extensive range of glass and BioBLU® Single-Use Vessel options (250 mL to 40 L). Universal connec- tions for digital and analog sensors make it easy to monitor a variety of critical process parameters. The embedded software offers real-time, local, process control through an integrated touchscreen. The newly developed auto culture modes for push- button control of microbial and cell-culture applications drastically reduce the learning curve associated with new equipment. For additional process control capabilities and secure database management, the BioFlo 120 can also be connected to Eppendorf SCADA platforms DASware® and BioCommand®. Eppendorf Fluorescent Staining Kits RediStain™ fluorescent kits for improved visualiza- tion of Caenorhabdi- tis elegans' structure and function in phenotyping studies. These kits expand the toolkit of C. elegans research to include the ability to perform structural and functional assays that are standard in cell biology. Used with the company's ScreenChip system (an automatic screening and phenotyping platform), the new staining kits provide a more efficient way to study nematode phenotypes and their directly related, underlying genotypes, which would not be possible with nonfluorescent techniques. The ScreenChip system is currently being used in aging, neurodegenerative, and cardiac diseases studies, as well as in drug development and developmental biology. NemaMetrix

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