Genetic Engineering & Biotechnology News

JUN15 2018

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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The team believes its work opens the door to new av- enues of bioelectrical research and novel forms of im- plantable medical devices. Graphene is one of those discoveries of materials science with properties that can seem straight from science fiction: A two-dimensional structure of pure carbon, the atoms arranged in a hexagonal lattice one atom thick, graphene has a tensile strength more than 200 times that of steel while weighing in at less than a gram per square meter, and is an excellent electri- cal conductor—attributes that make graphene appeal- ing for use in everything from consumer electronics to scaffolding for bone tissue engineering. see page 10 Jon Kelvey Scientists at the University of California-San Diego (UCSD) have used the ability of graphene to convert light to electricity in order to pace and control heart cells cultured on the semimetal. Lighting Up the Heart John Sterling Last month President Trump announced his plan for reducing drug prices for Americans. Details were con- tained in a government document entitled "American Patients First: The Trump Administration Blueprint to Lower Drug Prices and Reduce Out-of-Pocket Costs." "One of my greatest priorities is to reduce the price of prescription drugs," said the president. "In many other countries, these drugs cost far less than what we pay in the United States. That is why I have directed my administration to make fixing the injustice of high drug prices one of our top priorities. Prices will come down." Working with the president, the Department of Health and Human Services (HHS) identified four chal- lenges in the American drug market: "high list prices for drugs; senior and government programs overpaying for drugs due to lack of the lat- est negotiation tools; high and President Reveals Plan to Cut Drug Prices see page 30 MaryAnn Labant When cell populations are analyzed, genomic, tran- scriptomic, and proteomic intricacies tend to lurk in the shadows that gather whenever average measurements are taken. When individual cells are analyzed, however, these intricacies may be brought to light. Turning dark blurs into vibrant mosaics is the business of single-cell analysis—and business is good. Single-cell analysis is yielding intriguing insights into cell and system develop- ment, the physiology of aging, the noncoding genome, and the molecular drivers of cancer and other diseases. Although still largely confined to a subset of devoted researchers, single-cell analysis is starting to enjoy wid- er use, growing as single-cell platforms become more accessible, as expertise is gained and disseminated, and as diverse methodologies gel. With its emphasis on the individual, single-cell anal- ysis is inherently democratic. How fitting, then, that single-cell analysis should show signs of being democ- ratized. In fact, at a recent single-cell event, Single Cell Genomics 2017, the stated theme was, "Sometimes the sum of the parts is greater than the whole." This event, which was held at the Weizmann Institute of Science, attracted single-cell pioneers and experts eager to share Single-Cell Analysis for a More Perfect Cell Biology see page 16 Current techniques for testing new antiarrhythmia or antitachycardia drugs involve cultured cardiomyocytes that are contracting at their own rate. Graphene could provide a way to pace cardiomyocytes to the exact state the drug is intended to treat. Matthias Tungen/Getty Images See Story on p26. Global Molecular Diagnostics Market $8.6 billion 2017 $20.7 billion Source: Coherent Market Insights (CAGR 11.5%) 2025 GENengnews.com June 15, 2018 The Scoop Top 10 Under 40: Biopharma's Emerging Leaders 6 Developing Detection Tools for Gasdermin E 19 New Cell Signaling Pathways Mapped 12 Molecular Diagnostics Brings Patients Hope 26

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