Genetic Engineering & Biotechnology News

JUN15 2018

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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Contents • Volume 38, Number 12 • June 15, 2018 What's Trending Online G E N E X C L U S I V E S The Reality of Puerto Rico after Maria Big Pharma Provides Resilience and Hope G E N N E W S H I G H L I G H T S CRISPR Eradicates Latent HIV-1, Offering Hope of "Functional Cures" T H E L I S T S Genomics Gets Personal Despite Data and Privacy Challenges, Decreasing Cost Ushers in the Age of Personalized Whole-Genome Sequencing G E N N E W S H I G H L I G H T S Protein in Breast Cancer Found to Be Essential for Metastasis Carola Schropp Meletios Verras/Getty Images Goyette et al., 2018, Cell Reports 23, 1476–1490 Stanislaw Pytel / Getty Images New Cell Signaling Pathways Mapped Cell signaling to aid cartographers of cardiovascular disease. 12 Disrupting Downstream Bottlenecks Upstream innovations leave little time for downstream operations to catch a breather. 20 Lighting Up the Heart Graphene plates use light-induced electricity to make cardiomyocytes "beat." 1 The Scoop 6 Top 10 Under 40 Excellence plus youth equals a persistent stream of significant contributions to the biopharma field. 4 Sticky Ends 32 Calendar 33 People 34 Best of the Web 35 New Products Molecular Diagnostics Brings Patients Hope Advancements in next-generation sequencing pave the way for researchers to discover more about the pathways of drug resistance. 26 Single-Cell Analysis for a More Perfect Cell Biology Sometimes less is more as honing in on a single cell, instead of a group, grants new insights. 1 President Trump Reveals Plan to Cut Drug Prices President wants to make what he calls the injustice of high drug prices one of his top priorities. His plan, however, is not without controversy. 1 Drug Discovery Tutorial 14 Validating Anti- Idiotypic Binders for Trastuzumab Avacta intends to allow for enhanced accuracy via Affimer reagents. OMICS Tutorial 19 Developing Detection Tools for Gasdermin E Programmed cell death involving GSDME appears to exacerbate the adverse side effects of chemotherapy. Bioprocessing Tutorial 24 Elemental Packing for Downstream Processing Pack it up and pack it in because the wave of elemental packing is about to begin. Translational Medicine 28 Prevent Cancer Immunotherapy's Side Effects Autoantibodies are essential for profiling patients to discern immunotherapy treatment efficacy. Corporate Profile 8 Phoseon Technology's UV LEDs Detect and Disinfect The electromagnetic spectrum has nothing on the spectrum of applications of UV light in the lab.

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