Genetic Engineering & Biotechnology News

JUL 2018

Genetic Engineering & Biotechnology News (GEN) is the world's most widely read biotech publication. It provides the R&D community with critical information on the tools, technologies, and trends that drive the biotech industry.

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4 | JULY 2018 | Genetic Engineering & Biotechnology News | GENengnews.com 140 Huguenot Street, New Rochelle, NY 10801- 5215 914 740 -2100 • GENengnews.com PUBLISHER & CEO Mary Ann Liebert PRESIDENT, GEN Publishing Marianne Russell GEN GROUP PUBLISHER Sande Giaccone EVP, STRATEGIC DEVELOPMENT Kevin Davies, Ph.D. EDITOR IN CHIEF John Sterling editor@GENengnews.com P R O D U C T I O N E D I TO R Robert M. Reis S E N I O R E D I TO R Kevin Mayer T E C H N I C A L E D I TO R Jeffrey S. Buguliskis, Ph.D. S E N I O R N E W S E D I TO R Alex Philippidis C H I E F CO PY E D I TO R Steven Hernacki A R T D I R E C TO R James Lambo C H I E F I N F O R M AT I O N O F F I C E R, V P Joe Cruz COMMERCIAL DIREC TOR Bill Levine D I G I TA L P R O D U C T M A N AG E R Sean Helmes ONLINE EDITORIAL SUPERVISOR Katherine Vuksanaj D I G I TA L P R O D U C T M A N AG E R Thomas Mathew W E B P R O D U C E R Melinda Kucsera A S S O C. D I R E C TO R O F M A R K E T I N G Jennifer Gatti S A L E S A D M I N I S T R ATO R Fallon Murphy I N T E R N Everett S. Weinstein GEN Editorial & Scientific Advisory Board Peter Banks, Ph.D., Scientific Director, BiotTek Instruments; Roslyn (Brandon) Hendriks, D.V.M., Managing Partner at C-Suite Corporate, The University of Queensland; Robert Clarke, Ph.D., President & CEO, Pulmatrix; Pete Gagnon, Chief Scientific Officer, BIA Separations; Uwe Gottschalk, Ph.D., Chief Scientific Officer, Lonza; Harry E. Gruber, M.D., CEO, Tocagen; Jin Seok Hur, Ph.D., Technology Director, Novasep; James Inglese, Ph.D., Investigator at National Center for Advancing Translational Sciences; Guenter Jagschies, Senior Director, GE Healthcare Life Sciences; Peter Johnson, M.D., Principal, MedisurgePI; Anis H. Khimani, Ph.D., Head of Strategy and Marketing, Research Reagent Solutions, PerkinElmer; Mikael Kubista, Ph.D., CEO and Founder, TATAA Biocenter; Peter Levison, Senior Marketing Director, Downstream Processing, Pall Life Sciences; Jan Lichtenberg, Ph.D., CEO and Co-Founder, InSphero; Miodrag MIcic, Sc.D., Ph.D., Professor and Department Chairman, Cerritos College; Eric Schadt, Ph.D., Founder and CEO, Sema4; Zhiwei Song, Ph.D., Scientist, National University of Singapore; Sumio Sugano, M.D., Ph.D., Professor, Medical Genomics, University of Tokyo; John Talley, Ph.D., Medicinal Chemist, Euclises Pharmaceuticals; Bin Wang, PhD., Professor, Principal Investigator, Fudan University Medical College; Daniel Wang, PhD., Institute Professor of Chemical Engineering, MIT Advertising United States and North America EAST COAST Monica Lieberman 914 740 2173 mlieberman@GENengnews.com MIDWEST/S.EAST Rick Bongiovanni 330 998 9800 rbongiovanni@GENengnews.com WEST COAST Catherine McConville 415 416 8970 cmcconville@GENengnews.com U.K. and Europe Ian Slade +44 7768 397068 islade@GENengnews.com GEN Classified, Asia and Australia Display Victoria Palusevic 914 740 2167 vpalusevic@GENengnews.com All Other Countries advertising@GENengnews.com 914 740 2200 List Sales: Scott Perillo 914 740-2178 sperillo@GENengnews.com Insertions and Advertising Material Wanda Sanchez wsanchez@GENengnews.com Customer Service & Subscriptions www.GENengnews.com/subscription-center 888 211 4235 847 559 7587 Reprints Karen Ballen reprints@GENengnews.com 914 740 2100 The views, opinions, findings, conclusions, and recommendations set forth in any article in Genetic Engineering & Biotechnology News (GEN) are solely those of the authors of those articles and do not necessarily reflect the views, policy, or position of GEN, its Publisher, or its editorial staff and should not be attributed to any of them. All advertisements are subject to review by the Publisher. The acceptance of advertisements does not constitute an endorsement of the product or service advertised. Genetic Engineering & Biotechnology News (ISSN-1935-472X) is published semimonthly except July, August, and December (twenty-one issues a year) by GEN Publishing, 140 Huguenot Street, 3rd Floor, New Rochelle, NY 10801-5215. Periodicals postage paid at New Rochelle, NY and at additional mailing offices. Postmaster: Send address changes to Genetic Engineering & Biotechnology News, c/o Subscription Department, Mary Ann Liebert, Inc., 140 Huguenot Street, 3rd Floor, New Rochelle, New York 10801-5215. Fax: 914 740-2201. Mailed in Canada under CPC CPM #40026674. Printed in the U.S.A. For subscription information go to: www.GENengnews.com/subscription-center Copyright © 2018 by GEN Publishing, New Rochelle, NY. Mary Ann Liebert, Inc. is recognized as a Certified Woman-Owned Business by the Women's Business Enterprise National Council (WBENC). GENengnews.com Nils O. Lindstrom and Tracy Tran / McMahon Lab USC Stem Cell GerolamoAuricchio/EyeEm/Getty Images Forget wrinkle creams, Botox, and cosmetic surgery. They won't remove the wrinkles that really count—the wrinkles in the nuclear lamina, the inner surface of the nuclear membrane. As the nuclear lamina accumulates wrinkles, it creates openings for transcription factors, which can then find their way to heterochromatin, tightly packed DNA. This DNA, which should be turned off, gets turned on instead, tipping cells toward dysfunction. Such changes in gene expression occur in old liver cells, observed scientists at the University of Virginia. Reporting in Aging Cell, the scientists associated laminar wrinkles with increased Foxa2 binding, de-repression of PPAR- and LXR-dependent gene expression, and development of fatty liver. Laminar wrinkles could also occur in other cell types, suggested the scien- tists, who added that the wrinkles could be removed if the nuclear membrane's lamin losses could be reversed, pos- sibly by lamin-transporting viruses. Just don't expect to see viral treatments at a spa anytime soon. A team of researchers from University of Southern California (USC) have been studying how nephron-forming progenitor cells (NPCs) become mature cell types in the kidney. The team genetically labelled in vitro mouse kidney NPCs and observed them with time-lapse microscopy. The team then used single-cell RNA-seq to document how NPCs turn into intermediate cell types with specific gene activity, which identifies them as the precursors to particular mature cell types. The results of this study were published in Developmental Cell. The team was able to interpret which genes were activated when specific cell types formed in the nephron. The researchers learned that early-arriving NPCs differ- entiate and become the tubule, which controls the reabsorption of im- portant compounds back into the blood and carries urine away. Later arrivals develop into the glomerulus, which filters blood. "Timing is critical in determining the type of mature cell that each progenitor will become," said Nils O. Lindstrom, Ph.D., a principal author of the study and a research associate in stem cell biology and regenera- tive medicine at USC's Keck School of Medicine. To develop better ani- mal models for drug development, scientists need to understand how these precursor cells form organs under normal circumstances. In addi- tion, these insights could facilitate the future manufacturing of organs for transplant. Kidney Progenitor Cells: Now Arriving They're not fingerprints, but microbial signatures constituting the unique microbial makeup of each individual can similarly identify persons involved in burglaries and other crimes that occur in the home, a study suggests. A team of researchers collected samples from the nostrils and hands of residents, and various surfaces from their respective homes in Chicago, IL, and Fort Lauderdale, FL, before and after mock burglaries by nonresidents. The investigators identified unique bacterial assemblages for each in- dividual, and generated models to discern the accuracy of predicting a nonresident interacting with a given home. A total of 9,965 unique operational taxonomic units (uOTUs) were identified among 30 individuals. Nonresidents' uOTUs were mapped to residents' home, showing an interaction accuracy of more than 60%. Observing the change in uOTUs over time, researchers found that appearance/disap- pearance rates showed no significant dif- ference in the absence or presence of other individuals. "With further improvement in detection of stable markers, the human microbiome may serve as an additional tool for human profiling and crime scene investigations," said Jarrad Hampton-Marcell, a Ph.D. candi- date at University of Illinois at Chicago and microbial ecologist at Argonne National Laboratory. Hampton-Marcell presented the study findings at ASM Microbe, the annual meet- ing of the American Society for Microbiol- ogy, held June 7–11 in Atlanta, GA. Microbial "Fingerprints" Betray Would-Be Burglars How To Reverse Aging : Remove Nuclear Wrinkles Sticky Ends...

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