Contents
www.GENengnews.com • Volume 34, Number 14 • August 2014
News
6 Sticky Ends
8 Products & Services Deals
10 Industry Watch
12 Discovery & Development
18 Genomics & Proteomics
24 Bioprocessing
34 Molecular Diagnostics
37 Clinical Trials
38 New Products
40 Calendar
40 Company Index
41 People
42 Best of the Web
Tutorials
Drug Discovery Tutorial
16 Analysis of Rat Kidney
Injury Biomarkers
Using Gyros technology, EMD Millipore developed a
nanoliter-scale assay to evaluate drug-induced toxicity.
OMICS Tutorial
20 Single-Cell Approach to
Personalized Medicine
To untangle cell lineage relationships in cancer,
BGI Tech is isolating and sequencing genomes
with single-cell precision.
Bioprocessing Tutorial
30 Imaging Microbial Culture O
2
Consumption
Respiratory dynamics can be monitored at the
colony scale, says PreSens, with incubator-embedded
2D sensor foils.
Bioprocessing Tech Note
32 Analyzing Process Tank Residues
According to McCrone, a polystyrene knife may
be the best tool for removing residues that
are fated for analysis.
NGS Ready for Clinical
Oncology Testing
One, two, or even a few genomic "hotspots" just aren't enough for
clinical genomics to catch fre, but it soon may be set ablaze by whole-
exome and whole-genome sequencing. PAGE 1
Real-Time PCR: Yet More
Worlds to Conquer
Its academic domain secure, real-time PCR overcomes data-
quality and usability barriers to extend its realm to translational
and applied markets. PAGE 18
Finer Screens for
Circulating Tumor Markers
They can circulate, but they can't hide—even the most elusive tumor cells
and bits of cell-free DNA are getting caught in tighter antigenic and
genetic dragnets. PAGE 1
FEATURES
Single-Use Bioreactors
Dare to Scale
From pilot-scale processing to GMP-compliant manufacturing,
single-use bioreactors boast of better sensors, improved
automation, and fner controls. PAGE 24
Columns
Point of View
8 FDA Gets Social
with Biopharmas
Draft guidance documents may reduce
uncertainty over social media norms, boosting
pharma networking.
Corporate Profle
10 Enzymatics Enriches NGS
with AMP
With ArcherDx' target-enrichment technology,
Enzymatics moves up the value chain, from
reagents to diagnostic tests.
Bioprocessing Perspectives
28 Embracing the Innovation
Imperative
A Sartorius Stedim Biotech exec is bullish on new drug
classes, bearish on continuous processing, and inclined
to hedge on biosimilars.