Simple Method Development for
Charge Variant Characterization
High-Resolution Separation and Unequalled High Resolution of
Analysis of Monoclonal Antibody Protein Variants
Thermo Scientifc™ ProPac™ line of
Variants
The Thermo Scientifc™ MAbPac™
SCX resin technology is the basis for
the superior performance of monoclonal
antibody variant analysis. The nonporous
core particle provides high rates of mass
transfer, which results in high effciency
separations.
A proprietary hydrophilic layer and grafted
cation-exchange surface provides pH
selectivity control and high-resolution
separations.
ion-exchange columns provide highresolution, high-effciency separations of
proteins. The rigid, nonporous pellicular
resin provides exceptionally high resolving
power, permitting the separation of
proteins that differ by as little as one
charged residue.
separation of glycans by charge, size and
polarity. It is designed for high-resolution
and high-throughput analysis with unique
selectivity for biologically important
glycans, either labeled or native, by
LC-fuorescence and LC-MS methods.
thermoscientifc.com/glycanpac
Columns for Simultaneous
Separation of Glycans by
Charge, Size and Polarity
The Thermo Scientifc™ GlycanPac™
AXH-1 is a high- performance, silicabased HPLC column for simultaneous
The Thermo Scientifc™ pH gradient
platform accelerates method development
and facilitates method transfer to QA/
QC for a wide range of protein and
MAb charge variants, through a generic
LC-based approach to charge variant
characterization.
thermoscientifc.com/phgradientbuffer
Accelerate
On-demand Webinar: Achieving
Higher Throughput and
Productivity in Monoclonal
Antibody Characterization
With an increasing number of monoclonal antibody (MAb) drug candidates in the
The webinar discusses how innovative
column chemistries and techniques
can be used to develop robust
high throughput methods for MAb
characterization.
biopharminternational.com/achieving
pipeline, high throughput and productivity in MAb characterization has never been
more important. Meet the increasing demands for faster and more detailed results with
Thermo Scientifc™ best-in-class LC columns and solutions.
MAb characterization
High Performance Affnity
Column for Monoclonal Antibody
Titer Analysis
• Analytical tools for greater productivity visit: thermoscientifc.com/bioLC
Charge Variants
The Thermo Scientifc™ MAbPac™
Protein A column is a high performance
affnity chromatography column
specifcally designed for fast, accurate
determination of monoclonal antibody
concentration in the harvest cell culture.
Size Exclusion Chromatography
Column Designed for MAb
Characterization
The Thermo Scientifc™ MAbPac™
SEC column is a high size exclusion
chromatography (SEC) column designed
for MAb characterization, including the
separation of monomers, aggregates, and
fragments; stable under both denaturing
and non-denaturing conditions, using
high-salt, low-salt, or volatile mobile
phases.
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